文献类型：期刊文献

英文题名：Chiral iminophosphorane catalyzed asymmetric sulfenylation of 4-substituted pyrazolones

作者：Han, Jianwei[1,2];Zhang, Yanxia[1,2];Wu, Xin-Yan[1];Wong, Henry N. C.[2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Fine Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai Hong Kong Joint Lab Chem Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China

年份：2019

卷号：55

期号：3

起止页码：397

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000454919600030)，CCR-EXPANDED(收录号:WOS:000454919600030)】；

基金：The work was supported by the National Natural Science Foundation of China (NSFC 21472213), National Key Research and Development Program (2016YFA0200302) and by Croucher Foundation (Hong Kong) in the form of a CAS-Croucher Foundation Joint Laboratory Grant.

语种：英文

摘要：An excellent level of enantioselectivity in asymmetric sulfenylation of 4-substituted pyrazolones was achieved with chiral iminophosphorane as the organocatalyst under continuum solvation conditions (up to 99% ee). Importantly, this catalytic process features high efficiency with excellent enantioselectivities, easy separation of products, low catalytic loadings and scale-up to grams without loss of enantioselectivity.