文献类型：期刊文献

英文题名：Organometallic and Enzymatic Catalysis for Ring Opening Copolymerization of ε-Caprolactone and 4-methyl-ε-Caprolactone

作者：Wang, Cui[1];Xiao, Yan[1];Heise, Andreas[2];Lang, Meidong[1]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Shanghai Key Lab Adv Polymer Mat,Key Lab Ultrafin, Shanghai 200237, Peoples R China;[2]Dublin City Univ, Sch Chem Sci, Dublin 9, Ireland

年份：2011

卷号：49

期号：24

起止页码：5293

外文期刊名：JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

收录：;EI(收录号：20114514506704);WOS:【SCI-EXPANDED(收录号:WOS:000297946000018)】；

基金：This research was supported by the Fundamental Research Funds for the Central Universities (WD0913008, WD1014017), "Shu Guang" Project of Shanghai Municipal Education Commission, the National Natural Science Foundation of China (51103041), the Natural Science Foundation of Shanghai (11ZR1409200). Shanghai Leading Academic Discipline Project (B502) and Shanghai Key Laboratory Project (08DZ2230500).

语种：英文

外文关键词：degradation; enzymatic catalysis; kinetics (polym.); particle formation; ring-opening polymerization

摘要：A series of copolymers containing epsilon-caprolactone (CL) and 4-methyl-epsilon-caprolactone (MeCL) were synthesized by ring-opening polymerization (ROP) using Tin(II) bis(2-ethylhexanoate)(Sn(Oct)(2)) or Novozym 435 as catalyst. The molecular structure and weight of copolymers were determined by nuclear magnetic resonance (NMR) and size exclusion chromatography (SEC), respectively. Our kinetic study showed that the monomer reactivity ratios for CL (r(1)) and MeCL (r(2)) using Sn(Oct) 2 as catalyst were estimated to be near unity and r(1) x r(2) = 1, indicating the random distribution of the monomers in the final copolymer. The results of DSC and XRD consistently indicated that the copolymers were inclined to be amorphous with the increasing of MeCL fraction. Microspheres were prepared from copolymers and characterized by SEM. The preliminary degradability and biocompatibility studies on these copolymers were also assessed. (C) 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 49: 5293-5300, 2011