文献类型：期刊文献

英文题名：Large-Scale Solvent-Free Chlorination of Hydroxy-Pyrimidines, -Pyridines, -Pyrazines and -Amides Using Equimolar POCl₃

作者：Wang, Han[1,2];Wen, Kun[2];Wang, Le[2];Xiang, Ye[2];Xu, Xiaocheng[2];Shen, Yongjia[1];Sun, Zhihua[2]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Shanghai Univ Engn Sci, Coll Chem & Chem Engn, Shanghai 201620, Peoples R China

年份：2012

卷号：17

期号：4

起止页码：4533

外文期刊名：MOLECULES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000303309900065)】；

基金：Financial support of this work was provided by Shanghai Saijia Chemicals Ltd., funding of Shanghai University of Engineering Science (2011XZ02,2011Q11), and the Special Scientific Foundation for Outstanding Young Teachers in Shanghai Higher Education Institutions (shgcjs023), Shanghai, China.

语种：英文

外文关键词：solvent-free; chlorination; phosphorous oxychloride (POCl3)

摘要：Chlorination with equimolar POCl3 can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.