文献类型：期刊文献

英文题名：Injectable Hydrogel with NIR Light-Responsive, Dual-Mode PTH Release for Osteoregeneration in Osteoporosis

作者：Kuang, Lijun[1];Huang, Jinghuan[2];Liu, Yutong[1];Li, Xiaolin[2];Yuan, Yuan[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Meilong Rd 130, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Orthopaed Surg, Yishan Rd 600, Shanghai 200233, Peoples R China

年份：2021

卷号：31

期号：47

外文期刊名：ADVANCED FUNCTIONAL MATERIALS

收录：;EI(收录号：20213510824608);WOS:【SCI-EXPANDED(收录号:WOS:000688526200001)】；

基金：L.K. and J.H. contributed equally to this work. The authors wish to express their gratitude to the financial supports from National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), Frontiers Science Center for Materiobiology and Dynamic Chemistry (No. JKVD1211002), and the National Natural Science Foundation of China (Nos. 31771040, 31971264).

语种：英文

外文关键词：dual-mode release; injectable hydrogels; near-infrared light; osteoporotic bone repair; parathyroid hormone; pores formation

摘要：Effective treatments to overcome osteoblast/osteoclast imbalance are the key to achieving desirable bone regeneration for osteoporosis patients. When used for local bone repair, parathyroid hormone (PTH) often leads to either excessive osteoclasts under continuous exposure or insufficient osteoclasts with pulsatile release of PTH. Herein, an injectable multifunctional in situ-generated calcium phosphate nanoparticle (ICPN)-coordinated poly(dimethylaminoethyl methacrylate-co-2-hydroxyethyl methacrylate) (DHCP) hydrogel loaded with PTH for near-infrared (NIR)-stimulated release is developed to achieve bone regeneration in an ovariectomized (OVX) model. Photothermal-responsive poly(N-acryloyl glycinamide-co-acrylamide) PNAm-indocyanine green ICG-PTH microspheres (PIP MSs) endow a dual-mode release system with a sustained release at low concentrations, a pulse release of PTH, and in situ pore formation properties. The PIP MS-encapsulated DHCP hydrogel (DHCP-10PIP/d) is injected into the bone defects of OVX rats. Under NIR irradiation, the localized photothermal effects trigger on-demand PTH release and in situ micropores formation through the gel-sol transition of PIP MSs, and the repeated treatment is harmless to the bioactivity of PTH. This platform can enhance osteoblast and osteoclast activity at the same time both in vitro and in vivo and repair the cranial defects of OVX rats successfully. Overall, this work provides a promising strategy for PTH delivery to repair osteoporotic bone defects.