文献类型：期刊文献

英文题名：In Vivo Detoxification of Lipopolysaccharide by Antimicrobial Peptides

作者：Zhang, Wenxu[1,2];He, Jiangcheng[1,2];Wu, Junchen[1,2];Schmuck, Carsten[3]

机构：[1]East China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Univ Duisburg Essen, Inst Organ Chem, D-47057 Essen, Germany

年份：2017

卷号：28

期号：2

起止页码：319

外文期刊名：BIOCONJUGATE CHEMISTRY

收录：;EI(收录号：20220411529426);WOS:【SCI-EXPANDED(收录号:WOS:000394481700008)】；

基金：We thank the National Basic Research 973 Program (2013CB733700), NSFC/China (91529101 and 21572057) for financial support.

语种：英文

外文关键词：Cell membranes - Peptides - Bacteria

摘要：Abundant lipopolysaccharide (LPS) can result in sepsis and septic shock, indicating a serious Gram-negative bacterial contamination. We have developed a novel strategy based on dendritic antimicrobial peptides that can detoxify LPS. The dendritic antimicrobial peptides bind to LPS at the surface of Gram-negative bacteria, killing the bacteria but removing the LPS from the cell wall of dead Gram-negative bacteria, hence detoxifying pathogenic bacteria in its host cells and effectively improving survival of animals infected with Pseudomonas aeruginosa. Our findings provide a way to detoxify bacterial contamination.