文献类型：期刊文献

英文题名：Silica coating of luminescent quantum dots prepared in aqueous media for cellular labeling

作者：Ma, Yunfei[1];Li, Yan[1];Zhong, Xinhua[1]

机构：[1]E China Univ Sci & Technol, Inst Appl Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：60

起止页码：543

外文期刊名：MATERIALS RESEARCH BULLETIN

收录：;EI(收录号：20143900073629);WOS:【SCI-EXPANDED(收录号:WOS:000347583100077)】；

基金：We thank the National Natural Science Foundation of China (No. 21175043 and 21301059), Chenguang Program of the Shanghai Education Commission (11CG31), the Science and Technology Commission of Shanghai Municipality (11 JC1403100,12NM0504101), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Quantum dots; Silica coating; B. Luminescence; Bioapplication

摘要：Silica coating is an effective approach for rendering luminescent quantum dots (QDs) with water dispersibility and biocompatibility. However, it is still challenging to prepare silica-coated QDs (QD@SiO2) with high emission efficiency, small size and great stability in favor for bioapplication. Herein, we reported a modified Stober method for silica coating of aqueously-prepared CdTe/CdS QDs. With the coexistence of Cd2+ and thioglycolic acid (TGA), a thin silica shell was formed around QDs by the hydrolysis of tetraethyl orthosilicate (TEOS). The resultant QD@SiO2 with a small size (similar to 5 nm in diameter) exhibits significantly higher emission efficiencies than that of the initial QDs. Also, QD@SiO2 has extraordinary photo and colloidal stability (pH range of 5-13,4.0 M NaCl solution). Protected by the silica shell, the cytotoxicity of QDs could be reduced. Moreover, the QD@SiO2 conjugated with folic acid (FA) presents high specific binding toward receptor-positive HeLa cells over receptor-negative A549 cells. (C) 2014 Elsevier Ltd. All rights reserved.