文献类型：期刊文献

英文题名：A Multifunctional Nanozyme with NADH Dehydrogenase-Like Activity and Nitric Oxide Release under Near-Infrared Light Irradiation as an Efficient Therapeutic for Antimicrobial Resistance Infection and Wound Healing

作者：Wang, Yi[1];Shi, Hong-dong[4];Zhang, Hai-Lin[1];Yu Chen, Yu-[2];Ren, Bing[1];Tang, Qi[1];Sun, Qi[3];Zhang, Qian-Ling[2];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Guangdong, Peoples R China;[3]Shenzhen Univ, Int Canc Ctr, Med Sch, Dept Pharmacol,Guangdong Prov Key Lab Reg Immun &, Shenzhen 518060, Guangdong, Peoples R China;[4]Kunming Med Univ, Sci & Technol Achievement Incubat Ctr, Yunnan Key Lab Stem Cell & Regenerat Med, Kunming 650500, Yunnan, Peoples R China

年份：2023

卷号：12

期号：25

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20232614311780);WOS:【SCI-EXPANDED(收录号:WOS:001013782300001)】；

基金：Acknowledgements This study was financially supported by the National Natural Science Foundation of China (Nos. 21571062 and 22177078), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to J.-G.L., and the Fundamental Research Funds for the Central Universities (No. 222201717003).

语种：英文

外文关键词：antibacterial efficacy; antimicrobial resistance infection; Cu-doped graphene quantum dots; nitric oxide; wound healing

摘要：In recent years, antimicrobial resistance (AMR) has become one of the greatest threats to human health. There is an urgent need to develop new antibacterial agents to effectively treat AMR infection. Herein, a novel nanozyme platform (Cu,N-GQDs@Ru-NO) is prepared, where Cu,N-doped graphene quantum dots (Cu,N-GQDs) are covalently functionalized with a nitric oxide (NO) donor, ruthenium nitrosyl (Ru-NO). Under 808 nm near-infrared (NIR) light irradiation, Cu,N-GQDs@Ru-NO demonstrates nicotinamide adenine dinucleotide (NADH) dehydrogenase-like activity for photo-oxidizing NADH to NAD(+), thus disrupting the redox balance in bacterial cells and resulting in bacterial death; meanwhile, the onsite NIR light-delivered NO effectively eradicates the methicillin-resistant Staphylococcus aureus (MRSA) bacterial and biofilms, and promotes wound healing; furthermore, the nanozyme shows excellent photothermal effect that enhances the antibacterial efficacy as well. With the combination of NADH dehydrogenase activity, photothermal therapy, and NO gas therapy, the Cu,N-GQDs@Ru-NO nanozyme displays both in vitro and in vivo excellent efficacy for MRSA infection and biofilm eradication, which provides a new therapeutic modality for effectively treating MRSA inflammatory wounds.