文献类型：期刊文献

英文题名：Sequential Control over Thiol Click Chemistry by a Reversibly Photoactivated Thiol Mechanism of Spirothiopyran

作者：Liu, Zhenzhen[1,2];Liu, Tao[1,2];Lin, Qiuning[1,2];Bao, Chunyan[1,2];Zhu, Linyong[1,2]

机构：[1]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：54

期号：1

起止页码：174

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20150200405031);WOS:【SCI-EXPANDED(收录号:WOS:000347065100022)】；

基金：This work was supported by NSFC (21173078, 51273064, 2137084), 973 Project (2013CB733700), Shanghai Sci. Tech. Comm. (14YF1404700), and the China Postdoctoral Science Foundation (2014M550221).

语种：英文

外文关键词：click chemistry; hydrogels; photochemistry; polymers; spiro compounds

摘要：A novel photocontrolled thiol click chemistry based on spirothiopyran and maleimide is reported. Upon irradiation with =365nm light, the spirothiopyran can isomerize to the open merocyanine form, a thiophenolate group, which can rapidly react with maleimide. The unreacted MC will readily isomerize back to the starting spirothiopyran, which can be repeatedly photoactivated as needed. Thus, this reversible photoactivated thiol confers spatiotemporal sequential control on the thiol-maleimide reaction using only one type of photochemical reaction. Polymer post-functionalization and hydrogel building with subsequent multipatterning using different maleimide molecules in a temporal sequential manner indicate that this photocontrolled Michael addition reaction can modulate the specific chemical events in a sequence.