文献类型：期刊文献

英文题名：Photocaged prodrug under NIR light-triggering with dual-channel fluorescence: in vivo real-time tracking for precise drug delivery

作者：Guo, Zhiqian[1,2];Ma, Yaguang[1,2];Liu, Yajing[3];Yan, Chenxu[1,2];Shi, Ping[3];Tian, He[1,2];Zhu, Wei-Hong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Inst Fine Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2018

卷号：61

期号：10

起止页码：1293

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20182205241078);WOS:【SCI-EXPANDED(收录号:WOS:000446627600013)】；

基金：This work was supported by The National Natural Science Foundation of China (21788102, 21421004, 21636002, 21622602), National Key Research and Development Program (2016YFA0200300), Scientific Committee of Shanghai (14ZR1409700, 15XD1501400), Fok Ying Tong Education Foundation (142014), and Program of Introducing Talents of Discipline to Universities (B16017)

语种：英文

外文关键词：near-infrared cyanine dye; dual-channel fluorescence; drug-release; photocage; tumor targeting

摘要：Light-triggered drug delivery system is an effective strategy for precise diagnosis and therapy in cancer treatment. However, it suffers from difficultly balancing the dosimetry of drug with light dose and a lack of in vivo models for validating their clinical benefits. Here we report an unprecedented near-infrared (NIR) light photocaged cyanine-based prodrug Cy-CPT-Biotin with dual-channel fluorescence mode, enabling NIR light to precisely regulate where, when and how the intact and active prodrugs are delivered. The synergy of photochemical reaction and modulation in pi-conjugated polyene backbone of cyanine can fully perform distinct dual-channel fluorescence changes in a NIR light-mediated manner. The prodrug has striking characteristics of excellent tumor-targeting ability, real-time monitoring of the in vivo behaviors by dual-channel mode and NIR-light triggering, especially for achieving fine regulation and on-demand drug release in the precise dosimetry of drug with light dose in living animals. This optical orthogonality strategy that conjuncts with NIR light-triggered and dual-channel fluorescence in vivo imaging provides a powerful tool for in vivo real-time tracking and finely tuning the prodrug release for precise drug delivery.