文献类型：期刊文献

英文题名：Controlled-release of ibuprofen on multilayer mesoporous vesicle

作者：Bian, Zijun;Tang, Jing;Hu, Jun;Li, Jinxia;Xu, Shouhong[1];Liu, Honglai

机构：[1]E China Univ Sci & Technol, State Key Lab Chem & Engn, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2013

卷号：436

起止页码：1021

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20133816758767);WOS:【SCI-EXPANDED(收录号:WOS:000326416900126)】；

基金：This work is supported by the National Natural Science Foundation of China (Projects No. 21176066, 21076071), National Basic Research Program of China (No. 2013CB733501), the 111 Project of Ministry of Education of China (No. B08021), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Multilayer vesicle; Mesoporous channel; Drug carrier; Ibuprofen; Weibull model

摘要：A concentric multilayer vesicle with mesoporous channels in each layer was synthesized and used as a drug carrier. The average size of the vesicles was about 100-300 nm, with the cavities of an average distance of about 7 nm between every two layers, and the mesoporous channels of an average diameter of 3.4nm in each layer. Ibuprofen was selected as the drug model to investigate the vesicle's loading and releasing performance. The vesicle showed a fast loading with the ibuprofen capacity (weight ratio of ibuprofen to material) of 30% within 2 h, and a slow controllable release during about 15 h. The Weibull model can be successfully used to describe the release performance. The analysis results demonstrated that fast loading and slow release of the vesicle were mainly attributed to its mesoporous multilayer structure. (C) 2013 Elsevier B.V. All rights reserved.