文献类型：期刊文献

英文题名：One-Pot Synthesis of Bioadhesive Double-Network Hydrogel Patch as Disposable Wound Dressing

作者：Gao, Yi-Ming[1];Li, Zi-Yuan[2,3];Zhang, Xiao-Jie[1];Zhang, Junji[2,3];Li, Qing-Feng[1];Zhou, Shuang-Bai[1]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Plast & Reconstruct Surg, Sch Med, Shanghai 200011, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Sch Ch, Frontiers Sci Ctr Materiobiol & Dynam Chem,Key Lab, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr,Sch Ch, Frontiers Sci Ctr Materiobiol & Dynam Chem,Joint I, Shanghai 200237, Peoples R China

年份：2023

卷号：15

期号：9

起止页码：11496

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20230913654250);WOS:【SCI-EXPANDED(收录号:WOS:001441370300001)】；

基金：The authors gratefully acknowledge technical support from the Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine. The authors acknowledge the financial support from the National Natural Science Foundation of China (81971848, 81620108019, 22122803, and 22105070), Shanghai Sailing Program (20YF1410300), and the Postdoctoral Research Foundation of China (2020M671017). The project was supported by the Shanghai Municipal Key Clinical Specialty (shslczdzk00901), the Innovative Research Team of High-level Local University in Shanghai (SSMU-ZDCX20180700), and the Clinical Research Plan of SHDC (SHDC2020CR1019B and SHC2020CR402).

语种：英文

外文关键词：hyaluronic acid; polydopamine; bioadhesive; wound healing; wound dressing

摘要：Inventions of materials to achieve biocompatibility, bioadhesion, and easy manufacturing are the urgent demand for promoting wound healing in clinical treatment. Hyaluronic acid (HA) is probably the ideal candidate for current dressing materials due to its well-known biocompatibility. However, the unavoidable problem for HA dressings is their inherent low adhesiveness to wounds, which severely impairs their treatment efficacy, especially during body movement. Here, we report a one-pot facile fabrication of hybrid double-network polydopamine-HA (PDA-HA) hydrogel with significantly enhanced adhesiveness compared to the HA hydrogel. Besides the easy manufacturing and promoted effectiveness, the PDA-HA hydrogel could be vacuum-dried to form a patch, further benefitting from the convenience for storage and distribution. When applied on the wound, the PDA-HA patch quickly rehydrated by absorbing exudate and stuck tightly to the wound. The applied PDA-HA patches keep the wounds covered for more than 7 days against strenuous exercise. Thus, mouse full-thickness wounds treated with the PDA-HA patches exhibited increased healing rates, where epithelization was finished within 14 days. Moreover, the hydrogel dressing exhibited promoting effects on vascularization and cell proliferation/migration. Together with the easy manufacturing procedure, good adhesion/adaptation, and promotion of wound healing, the PDA-HA patch holds great potential for future clinical translation.