文献类型：期刊文献

英文题名：Hepatoprotective effects of 2′,4′-dihydroxy-6'-methoxy- 3′,5′-dimethylchalcone on CCl4-induced acute liver injury in mice

作者：Yu, Wan-Guo[1]; Qian, Jie[2]; Lu, Yan-Hua[1]

机构：[1] State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, China; [2] School of Life Sciences and Technology, TongJi University, Shanghai, China

年份：2011

卷号：59

期号：24

起止页码：12821

外文期刊名：Journal of Agricultural and Food Chemistry

收录：EI(收录号：20115214645660)

语种：英文

外文关键词：Diseases - Mammals - Peptides - Antioxidants - Amino acids - Lipids - Plants (botany) - Chlorine compounds - Phosphatases - Oxidation - Superoxide dismutase

摘要：In this paper, the hepatoprotective effects of 2′,4′-dihydroxy- 6′-methoxy-3′,5′-dimethylchalcone (DMC) on CCl 4-induced acute liver injury in Kunming mice were investigated. DMC was administered intraperitoneally (ip) (5, 10, or 20 mg/kg of body weight) for 7 days prior to the administration of CCl4 (0.1%, ip). Pretreatment with DMC significantly decreased activities of serum hepatic enzymes, namely alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase, γ-glutamyl transferase, and total bilirubin, and decreased the elevation of lipid peroxidation, malondialdehyde, reactive oxygen species, and protein carbonyl content. Pretreatment with DMC markedly increased activities of enzymatic antioxidants such as superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, glutathione S-transferase, and glutathione reductase and increased levels of nonenzymatic antioxidant markers such as reduced glutathione, total sulfhydryl groups, vitamin C, and vitamin E in liver. These results combined with liver histopathology demonstrate that DMC has potential hepatoprotective effects, which may be related to the attenuation of oxidative stress, accelerating the antioxidant cascade and inhibition of lipid peroxidation. ? 2011 American Chemical Society.