文献类型：期刊文献

英文题名：In-situ extraction and separation of salvianolic acid B from Salvia miltiorrhiza Bunge by integrated expanded bed adsorption

作者：Zhang, Min[1]; Yang, Huihua[2]; Chen, Xian[1]; Zhou, Yongchuan[1]; Zhang, Hongyang[3]; Wang, Yuerong[3]; Hu, Ping[3]

机构：[1] Modern Engineering Center for Traditional Chinese Medicine, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; [2] College of Computer Science and Control, Guilin University of Electronic Technology, Guilin 541004, China; [3] School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, China

年份：2011

卷号：80

期号：3

起止页码：677

外文期刊名：Separation and Purification Technology

收录：EI(收录号：20141617582100)

语种：英文

外文关键词：Extraction - Solutions - Environmental impact

摘要：This article describes the development of an integrated expanded bed extraction and separation method for in-situ recovery of salvianolic acid B from Salvia miltiorrhiza Bunge. Twenty-five grams of the herb was extracted in a dynamic extraction column for 3 h, while the target was simultaneously absorbed onto an expanded bed column without any further processing. Then, the expanded bed column was eluted with 1 bed volume (BV) of water and 5 BVs of 50% (v/v) ethanol aqueous solution with a flow rate of 2.4 BV/h. From this, 1438.8 mg of salvianolic acids, containing 55.7% of pure salvianolic acid B, was harvested with an 88.0% recovery. Six evaluation parameters - purity, recovery, process throughput, process efficiency, process environmental impact and general process evaluation - were used as indices for evaluation of different methods. The results indicate that the in-situ method we have developed is a promising process for the recovery of salvianolic acid B from the herb of S. miltiorrhiza Bunge. ? 2011 Elsevier B.V. All rights reserved.