文献类型：期刊文献

英文题名：Theranostic Activity of Nitric Oxide-Releasing Carbon Quantum Dots

作者：Jin, Haibao[1,3];Feura, Evan S.[1];Schoenfisch, Mark H.[1,2]

机构：[1]Univ North Carolina Chapel Hill, Dept Chem, Chapel Hill, NC 27599 USA;[2]UNC Eshelman Sch Pharm, Div Pharmacoengn & Mol Pharmaceut, Chapel Hill, NC 27599 USA;[3]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：32

期号：2

起止页码：367

外文期刊名：BIOCONJUGATE CHEMISTRY

收录：;EI(收录号：20220411529569);WOS:【SCI-EXPANDED(收录号:WOS:000621366800015)】；

基金：Financial support was provided by the National Institutes of Health (DE025207). FTIR tests in our research were performed using Bruker Alpha FTIR spectrometer funded by the UNC EFRC: Center for Solar Fuels, an Energy Frontier Research Center supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences, under Award No. DE-SC0001011. The Microscopy Services Laboratory, Department of Pathology and Laboratory Medicine, is supported in part by P30 CA016086 Cancer Center Core Support Grant to the UNC Lineberger Comprehensive Cancer Center.

语种：英文

外文关键词：Cell culture - Fluorescence microscopy - Reaction kinetics - Amines - Semiconductor quantum dots - Carbon - Nanocrystals

摘要：The synthesis and anticancer cell activity of nitric oxide (NO)-releasing carbon quantum dots (CQDs) are described as potential theranostics. A series of secondary amine-modified CQDs were prepared using a hydrothermal method to modify beta-cyclodextrin with hydroxyl and primary amine terminal functional groups. Subsequent reaction of the CQDs with NO gas under alkaline conditions yielded N-diazeniumdiolate NO donormodified CQDs with adjustable NO payloads (0.2-1.1 mu mol/mg) and release kinetics (half-lives from 29 to 79 min) depending on the level of secondary amines and surface functional groups. The anticancer activity of the NO-releasing CQDs against Pa 14c, A549, and SW480 cancer cell lines proved to be dependent on both NO payloads and surface functionalizations. Primary amine-modified CQDs with NO payloads similar to 1.11 mu mol/mg exhibited the greatest anticancer action. A fluorescence microscopy study demonstrated the utility of these NO-releasing CQDs as dual NO-releasing and bioimaging probes.