文献类型：期刊文献

英文题名：Self-Assembled Plasmonic Nanojunctions Mediated by Host-Guest Interaction for Ultrasensitive Dual-Mode Detection of Cholesterol

作者：Chen, Hua-Ying[1];Xin, Pei-Lin[1];Xu, Han-Bin[1];Lv, Jian[1];Qian, Ruo-Can[1];Li, Da-Wei[1]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat,Shanghai Key Lab Funct Mat Chem,Jo, Shanghai 200237, Peoples R China

年份：2023

卷号：8

期号：1

起止页码：388

外文期刊名：ACS SENSORS

收录：;EI(收录号：20230313388947);WOS:【SCI-EXPANDED(收录号:WOS:000913267100001)】；

基金：ACKNOWLEDGMENTS This work was financially supported by the National Natural Science Foundation of China (grant nos. 21788102, 21974046, 22176058, and 21977031) , the Science and Technology Commission of Shanghai Municipality (grant nos. 19391901700, 19520744000, and 19ZR1472300) , and the Fundamental Research Funds for the Central Universities. The authors thank Research Center of Analysis and Test of East China University of Science and Technology for the characterization.

语种：英文

外文关键词：surface-enhanced Raman spectroscopy; fluorescence; dual-mode; host-guest competition; plasmonic nanojunctions; cholesterol

摘要：Herein, a fluorescence and surface-enhanced Raman spectroscopy dual-mode system was designed for cholesterol detection based on self-assembled plasmonic nanojunctions mediated by the competition of rhodamine 6G (R6G) and cholesterol with s-cyclodextrin modified on gold nanoparticles (HS-s-CD@Au). The fluorescence of R6G was quenched by HS-s-CD@Au due to the fluorescence resonance energy transfer effect. When cholesterol was introduced as the competitive guest, R6G in the cavities of HS-s- CD@Au was displaced to recover its fluorescence. Moreover, two of HS-s-CD@Au can be linked by one cholesterol to form a more stable 2:1 complex, and then, plasmonic nanojunctions were generated, which resulted in the increasing SERS signal of R6G. In addition, fluorescence and SERS intensity of R6G increased linearly with the increase in the cholesterol concentrations with the limits of detection of 95 and 74 nM, respectively. Furthermore, the dual-mode strategy can realize the reliable and sensitive detection of cholesterol in the serum with good accuracy, and two sets of data can mutually validate each other, which demonstrated great application prospects in the surveillance of diseases related with cholesterol.