文献类型：期刊文献

英文题名：I2/TBHP-Promoted Approach to α-Keto Esters from Trifluoromethyl β-Diketones and Alcohols via C-C Bond Cleavage

作者：Shao, Tongle[1,2];Fang, Xiang[1,2];Zhou, Jun[1,2];Jin, Chen[1,2];Yang, Xueyan[1,2];Wu, Fanhong[3]

机构：[1]East China Univ Sci & Technol, Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Shanghai Inst Technol, Sch Chem & Environm Engn, 120 Caobao Rd, Shanghai 200235, Peoples R China

年份：2017

卷号：28

期号：15

起止页码：2018

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000411346000030)，CCR-EXPANDED(收录号:WOS:000411346000030)】；

基金：The authors thank the National Natural Science Foundation of China (No. 21672151) for financial support.

语种：英文

外文关键词：trifluoromethyl beta-diketones; alpha-keto esters; C-C bond cleavage; C-O coupling; alcohols

摘要：A metal-free oxidative coupling reaction of trifluoromethyl beta-diketones with alcohols for the synthesis of alpha-keto esters in good to excellent yields has been developed. Preliminary mechanistic studies suggest that an I-2/TBHP promoted sequential iodination, C-C bond cleavage, C-O bond formation and oxidation pathway is involved in this reaction.