文献类型：期刊文献

英文题名：Flash nanoprecipitation with Gd(III)-based metallosurfactants to fabricate polylactic acid nanoparticles as highly efficient contrast agents for magnetic resonance imaging

作者：Xu, Kehan[1];Wang, Mingwei[2];Tang, Weijun[3];Ding, Yun[1];Hu, Aiguo[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Huashan Hosp, Dept Radiol, Shanghai 200040, Peoples R China

年份：2020

卷号：15

期号：16

起止页码：2475

外文期刊名：CHEMISTRY-AN ASIAN JOURNAL

收录：;EI(收录号：20202808907732);WOS:【SCI-EXPANDED(收录号:WOS:000546456800001)】；

基金：The authors gratefully acknowlkedge the financial support from National Natural Science Foundation of China (21274042, 21503078), the Fundamental Research Funds for the Central Universities (22221818014), and Shanghai Leading Academic Discipline Project (B502). AH thanks the "Eastern Scholar Professorship" support from Shanghai local government.

语种：英文

外文关键词：Magnetic Resonance Imaging; Contrast Agents; Flash Nanoprecipitation; Self-assembly; Nanoparticles

摘要：Polylactic acid (PLA) nanoparticles coated with Gd(III)-based metallosurfactants (MS) are prepared using a simple and rapid one-step method, flash nanoprecipitation (FNP), for magnetic resonance imaging (MRI) applications. By co-assembling the Gd(III)-based MS and an amphiphilic polymer, methoxy poly(ethylene glycol)-b-poly(epsilon-caprolactone) (mPEG-b-PCL), PLA cores were rapidly encapsulated to form biocompatible T(1)contrast agents with tunable particle size and narrow size distribution. The hydrophobic property of Gd(III)-based MS were finely tuned to achieve their high loading efficiency. The size of the nanoparticles was easily controlled by tuning the stream velocity, Reynolds number and the amount of the amphiphilic block copolymer during the FNP process. Under the optimized condition, the relaxivity of the nanoparticles was achieved up to 35.39 mM(-1) s(-1)(at 1.5 T), which is over 8 times of clinically used MRI contrast agents, demonstrating the potential application for MR imaging.