文献类型：期刊文献

英文题名：The Action-Networks of Nanosilver: Bridging the Gap between Material and Biology

作者：Cao, Huiliang[1,2,3];Qin, Hui[4];Li, Yongsheng[1,2];Jandt, Klaus D.[3,5,6]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Lab Low Dimens Mat Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Engn Res Ctr Hierarch Nanomat, Shanghai 200237, Peoples R China;[3]Friedrich Schiller Univ Jena, Otto Schott Inst Mat Res, Chair Mat Sci, D-07743 Jena, Germany;[4]Shanghai Jiaotong Univ Affiliated Peoples Hosp 6, Dept Orthopaed, Shanghai 200233, Peoples R China;[5]Friedrich Schiller Univ Jena, Jena Ctr Soft Matter JCSM, D-07743 Jena, Germany;[6]Jena Sch Microbial Commun JSMC, Neugasse 23, D-07743 Jena, Germany

年份：2021

卷号：10

期号：18

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20213110697067);WOS:【SCI-EXPANDED(收录号:WOS:000678786200001)】；

基金：This work was supported by the National Natural Science Foundation of China (31870945 and 31771022). H.C. would like to thank the Alexander vonHumboldt Foundation for awarding aHumboldt Research Fellowship. K.D.J. gratefully acknowledges the partial support of the Collaborative Research Centre PolyTarget (SFB 1278, project A06) funded by the DFG.Open access funding enabled and organized by Projekt DEAL.

语种：英文

外文关键词：antimicrobials; implantable medical devices; nanobiology; nanomedicine; nanosafety

摘要：The emergence of nanosilver (silver in nanoscale shapes and their assemblies) benefits the landscape of modern healthcare; however, this brings about concerns over its safety issues associated with an ultrasmall size and high mobility. By reviewing previous reporting details about the synthesis and characterization of nanosilver and its biological responses, a gap between materials synthesis and their biomedical uses is characterized by the insufficient understanding of the interacting and interplaying nanoscale actions of silver. To improve reporting quality and advance clinical translations, it is suggested that researchers have a comprehensive recognition of the "Indications for use" before designing innovative nanosilver-based materials and an "Action-network" concept addressing the acting range and strength of those nanoscale actions is implemented. Although this discussion is specific to nanosilver, the idea of "Indications for use" centered design and synthesis is generally applicable to other biomedical nanomaterials.