文献类型：期刊文献

英文题名：Recent advances in fluorescent glycoconjugate probes for biosensing, bioimaging and targeted photodynamic therapy

作者：Han, Hai-Hao[1,3,4];Hu, Xi-Le[1];He, Xiao-Peng[1,2]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat & Joint Int Re, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Second Mil Med Univ, Natl Ctr Liver Canc, Int Cooperat Lab Signal Transduct, Eastern Hepatobiliary Surg Inst, Shanghai 200433, Peoples R China;[3]Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Shandong, Peoples R China;[4]Chinese Acad Sci, Mol Imaging Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

年份：2025

卷号：61

期号：81

起止页码：15735

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20254119291340);WOS:【SCI-EXPANDED(收录号:WOS:001575560200001)】；

基金：The authors are grateful to the National Natural Science Foundation of China (No. 92253306, 22477030, 22377135, and 22107029), the Science and Technology Commission of Shanghai Municipality (grant no. 24DX1400200), the International Cooperation Program of Shanghai Science and Technology (No. 23490711600), the Shanghai Oriental Talents youth Program (No. QNKJ2024010), the Shanghai Xuhui District Hospital Local Cooperation Project (23XHYD-20), the Open Funding Project of the State Key Laboratory of Fine Chemicals, Dalian University of Technology (KF 2402), the Fundamental Research Funds for the Central Universities (222201717003), the Programme of Introducing Talents of Discipline to Universities (B16017), the Open Funding Project of the State Key Laboratory of Bioreactor Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, P.R. China, the Ministry of Education Key Laboratory on Signaling Regulation and Targeting Therapy of Liver Cancer (Naval Medical University) (grant 2023-MEKLLC-MS/ZD-00*), the Shandong Laboratory Program (SYS202205), the Taishan Scholars Program (No. tsqn202312305), the Young Elite Scientists Sponsorship Program by Chinese Chemical Society, the Fundamental Research Projects of Science & Technology Innovation and Development Plan in Yantai City (No. 2023JCYJ059), and the Key R&D Program of Shandong (No. 2024CXPT028).

语种：英文

外文关键词：Biocompatibility - Bioimaging - Diagnosis - Diseases - Fluorescence imaging - Probes - Theranostics

摘要：Fluorescent glycoconjugate probes have emerged as innovative tools for biomedical research, helping to delineate the mechanistic roles of sugars in biological and pathological events. This feature article reviews the recent advances in the development and application of fluorescent glycoconjugate probes since 2021, highlighting their applications for biosensing, targeted imaging and phototherapy. We describe the design principles of these probes, their utilization in the detection and cell imaging of glycosidase activities, and their potential to be developed as theranostic agents. We also discuss the challenges and future directions in this field, including the need for the development of sensitive, selective and biocompatible probes for early diagnosis and treatment of major human diseases such as cancer.