文献类型：期刊文献

英文题名：Inflammation Responses to Bone Scaffolds under Mechanical Stimuli in Bone Regeneration

作者：Wang, Junjie[1];Yuan, Bo[2];Yin, Ruixue[1];Zhang, Hongbo[1]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[2]Naval Med Univ, Shanghai Changzheng Hosp, Spine Ctr, Dept Orthopaed,Affiliated Hosp 2, Shanghai 200003, Peoples R China

年份：2023

卷号：14

期号：3

外文期刊名：JOURNAL OF FUNCTIONAL BIOMATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000955520300001)】；

基金：This research was funded by Shanghai Sailing Program (grant no. 21YF1458100), and Shanghai Changzheng Pyramid Project (grant no. YQ666).

语种：英文

外文关键词：inflammation; mechanical environment; bone regeneration; ultrasound; mechanical force

摘要：Physical stimuli play an important role in one tissue engineering. Mechanical stimuli, such as ultrasound with cyclic loading, are widely used to promote bone osteogenesis; however, the inflammatory response under physical stimuli has not been well studied. In this paper, the signaling pathways related to inflammatory responses in bone tissue engineering are evaluated, and the application of physical stimulation to promote osteogenesis and its related mechanisms are reviewed in detail; in particular, how physical stimulation alleviates inflammatory responses during transplantation when employing a bone scaffolding strategy is discussed. It is concluded that physical stimulation (e.g., ultrasound and cyclic stress) helps to promote osteogenesis while reducing the inflammatory response. In addition, apart from 2D cell culture, more consideration should be given to the mechanical stimuli applied to 3D scaffolds and the effects of different force moduli while evaluating inflammatory responses. This will facilitate the application of physiotherapy in bone tissue engineering.