文献类型：期刊文献

中文题名：粉唑醇的合成

英文题名：Synthesis of Fungicide Flutriafol

作者：曹伟锋[1];廖道华[1];雷子蕙[1]

机构：[1]华东理工大学制药工程系,上海200237

年份：2006

卷号：36

期号：4

起止页码：33

中文期刊名：精细化工中间体

外文期刊名：Fine Chemical Intermediates

收录：CSTPCD

语种：中文

中文关键词：杀菌剂;粉唑醇;氯乙醇;格氏反应;邻氟溴苯;合成

外文关键词：fungicide; flutriafol; ethanolyl chloride; Grignard reaction; o-fluorobenzyl bromide; synthesis

摘要：粉唑醇是用于植物叶片和穗的广谱杀菌剂,对谷物白粉病、云形病、叶斑病和锈病都有效。本文以邻氟溴苯为原料经格氏反应合成1-(2-氟苯基)-1-(4-氟苯基)-2-氯乙醇,然后与1,2,4-三唑钠盐反应得到标题化合物。总收率达59%,含量94.5%。
Flutriafol was a kind of broad-spectrum fungicide that could be used to control effectively cereal powdery mildew, cloud disease, leaf spot disease and rust disease. 1-o-fluorophenyl-1-p-fluorophenyl-2-chloroethanol was prepared through Grignard reaction starting with 2-fluorobenzyl bromide, and then reacted with sodium triazol to give the title product flutriafol. The total yield and purity were 59% and 94.5%, respectively.