文献类型：期刊文献

英文题名：Palladium- and Nickel-Catalyzed Kumada Cross-Coupling Reactions of gem-Difluoroalkenes and Monofluoroalkenes with Grignard Reagents

作者：Dai, Wenpeng[1];Xiao, Juan[1];Jin, Guanyi[1];Wu, Jingjing[2,3];Cao, Song[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China;[3]Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China

年份：2014

卷号：79

期号：21

起止页码：10537

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20144700216075);WOS:【SCI-EXPANDED(收录号:WOS:000344638200054)，CCR-EXPANDED(收录号:WOS:000344638200054)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grants 21472043, 21272070, and 21302128) and the National Basic Research Program of China (973 Program, 2010CB126101).

语种：英文

外文关键词：Chemical reactions - Nickel - Atoms

摘要：A novel Kumada-Tamao-Corriu cross-coupling reaction of gem-di- or monofluoroalkenes with Grignard reagents, with or without beta-hydrogen atoms, in the presence of a catalytic amount of palladium- or nickel-based catalysts has been developed. The reaction is performed under mild conditions (room temperature or reflux in diethyl ether for 1-2 h) and leads to di-cross- or mono-cross-coupled products in good to high yields.