文献类型：期刊文献

英文题名：Catalyst-Free ?-Alkylation-?-Hydroxylation of Oxindole with Alcohols

作者：Wu, Siwei[1,2,3];Song, Wei[1,2,3];Zhu, Runyu[1,2,3];Hu, Jingwen[1,2,3];Zhao, Lin[1,2,3];Li, Zheyao[1,2,3];Yu, Xinhong[1,2,3];Xia, Chengcai[4];Zhao, Jianhong[1,2,3]

机构：[1]East China Univ Sci & Technol, Minist Educ, Engn Res Ctr Pharmaceut Proc Chem, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Bioengn Reactors, Shanghai 200237, Peoples R China;[4]Taishan Med Univ, Sch Pharmaceut Sci, Inst Pharmacol, Tai An 271016, Shandong, Peoples R China

年份：2022

卷号：87

期号：9

起止页码：5464

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20221612005728);WOS:【SCI-EXPANDED(收录号:WOS:000818662400002)，CCR-EXPANDED(收录号:WOS:000818662400002)】；

基金：We gratefully acknowledge financial support from the National Science Foundation of China (21476078, X.-H.Y.), the National Science Foundation of Shandong Province (ZR 2017 LB006, C.-C.X.), and the Science and Technology Commission of Shanghai Municipality (No. 12431900902, X.-H.Y.).

语种：英文

外文关键词：Catalysts - Hydroxylation - Transition metals

摘要：3-Alkyl-3-hydroxyoxindoles, a subclass of oxindole products, have antioxidant, neuroprotective, anticancer, and anti-HIV activities. In this study, a green and economical protocol for the synthesis of 3-alkyl-3-hydroxyoxindoles is developed for the first time via alpha-alkylation-alpha-hydroxylation of oxindole with benzyl alcohols without using any transition-metal catalysts in yields of29-93%.