文献类型：期刊文献

中文题名：光学活性倍半萜β-桉烯类似物的合成及结构分析研究

英文题名：THE SYNTHESIS OF OPTICAL ACTIVE ANALOGUE OF β-SELINENE AND THE STUDY ON ITS STRUCTURE

作者：何平[1];段永熙[2]

机构：[1]中国科学院上海药物研究所,上海200031;[2]华东化工学院精细化工系,上海200237

年份：1992

卷号：2

期号：1

起止页码：1

中文期刊名：中国药物化学杂志

外文期刊名：Chinese Journal of Medicinal Chemistry

收录：CSTPCD;;CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：倍半萜;β-桉烯;(-)-β-蒎烯;二甲基铜锂;Wittig反应

外文关键词：Sesquiterpenes; β-Selinene; (-)-β-Pinene; Lithim dimethylcuprate;Wittig reaction

摘要：本文叙述了具有光学活性的倍半萜β-桉烯脱甲基类似物-(+)-9β-(2′-丙烯基)-2-羟基-2-甲基-双环[4,4,0]-1-癸烯(V),(+)-9β-(2′-丙烯基)-2-亚甲基-双环[4,4,O]-1-癸烯(Ⅵ)以及β-桉烯中间体(+)-8β-(2′-丙烯基)-1-甲基-双环[4,40]-5-癸酮(Ⅶ,Ⅶ,Ⅸ,Ⅹ)的合成。化合物(Ⅴ),(Ⅵ)迄今未见文献报道,它们的化学结构得到确证,对(Ⅵ)的合成途径及结构稳定性进行了探讨,发现其稳定性优于其同分异构体(Ⅻ).
The synthesis of optical active analogue of β-selinene, a member of the eudesmane class of sesquiterpenes, (+) -9β-(2′-propenyl)-2-hydroxy-2-methyl -bicyclo(4,4,0)-1-decanene (Ⅴ), (+) -9β- (2′-propenyl) -2-methene-bicyclo (4, 4,0)-1-decanene(Ⅵ), and β-selinene intermediate (+)-8β-(2′-propenyl)-1-methyl-5-decalone(Ⅶ,Ⅷ,Ⅸ,Ⅹ)was described in this paper.The compound (Ⅴ) and (Ⅵ) have not been reported in the literature and their structures were identified.Besides this,the synthetic routes and structure stability of compounds (Ⅵ) were also explored and it has been found that compound(Ⅵ)is more stable than its isomer(ⅩⅢ).