文献类型：期刊文献

英文题名：Myocardial regeneration: Roles of stem cells and hydrogels

作者：Ye, Zhaoyang[1];Zhou, Yan[1];Cai, Haibo[1];Tan, Wensong[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2011

卷号：63

期号：8

起止页码：688

外文期刊名：ADVANCED DRUG DELIVERY REVIEWS

收录：;EI(收录号：20112814134275);WOS:【SCI-EXPANDED(收录号:WOS:000293549700013)】；

基金：Financial support from the Fundamental Research Funds for the Central Universities, the National Special Fund for State Key Laboratory of Bioreactor Engineering (2060204), Shanghai Natural Science Foundation (10ZR1407100), Shanghai Pujiang Program (10PJ1402200) and National Natural Science Foundation of China (31000424) is gratefully acknowledged.

语种：英文

外文关键词：Myocardial regeneration; Cell therapy; Tissue engineering; Stem cells; Hydrogels

摘要：Heart failure remains the leading cause of morbidity and mortality. Recently, it was reported that the adult heart has intrinsic regenerative capabilities, prompting a great wave of research into applying cell-based therapies, especially with skeletal myoblasts and bone marrow-derived cells, to regenerate heart tissues. While the mechanism of action for the observed beneficial effects of bone marrow-derived cells remains unclear, new cell candidates are emerging, including embryonic stem (ES) and introduced pluripotent stem (iPS) cells, as well as cardiac stem cells (CSCs) from adult hearts. However, the very low engraftment efficiency and survival of implanted cells prevent cell therapy from turning into a clinical reality. Injectable hydrogel biomaterials based on hydrophilic, biocompatible polymers and peptides have great potential for addressing many of these issues by serving as cell/drug delivery vehicles and as a platform for cardiac tissue engineering. In this review, we will discuss the application of stem cells and hydrogels in myocardial regeneration. (C) 2011 Elsevier B.V. All rights reserved.