文献类型：期刊文献

中文题名：具有扭曲D-A-D转子结构的近红外光疗试剂能够 同时产生超氧自由基和光热用于消除乏氧肿瘤

英文题名：NIR-absorbing superoxide radical and hyperthermia photogenerator via twisted donor-acceptor-donor molecular rotation for hypoxic tumor eradication

作者：Zhu, Yucheng[1];Wu, Qinghua[2,3];Chen, Chao[1];Yang, Guoliang[1];Cao, Hongliang[1];Gao, Yun[1];Jiao, Lijuan[2,3];Hao, Erhong[2,3];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Anhui Normal Univ, State Key Lab Cultivat Base, Anhui Lab Mol Based Mat, Lab Funct Mol Solids,Minist Educ, Wuhu 241000, Peoples R China;[3]Anhui Normal Univ, Sch Chem & Mat Sci, Wuhu 241000, Peoples R China

年份：2021

卷号：64

期号：12

起止页码：3101

外文期刊名：SCIENCE CHINA-MATERIALS

收录：;EI(收录号：20213110712986);WOS:【SCI-EXPANDED(收录号:WOS:000679761600001)】；

基金：This work was supported by the National Natural Science Foundation of China (21875063 and 21871006), the Science and Technology Commission of Shanghai Municipality for Shanghai International Cooperation Program (19440710600), and the Open Funding Project of the State Key Laboratory of Bioreactor Engineering.

语种：中文

外文关键词：tumor hypoxia; superoxide radical; hyperthermia; D-A-D structure; molecular rotation

摘要：Hypoxia severely impedes the therapeutic efficacies of tumor chemotherapy, radiotherapy and conventional photodynamic therapy (type II PDT). Herein, we proposed a nonplanar near-infrared (NIR)-absorbing hyperthermia and superoxide radical (O-2(-center dot)) photogenerator (TB) against hypoxic tumors. TB particularly possessed a favorable O-2(-center dot) generation capability under 808 nm laser irradiation with the donor-acceptor-donor (D-A-D) molecular structure. Moreover, owing to molecular rotation, potent hyperthermia was realized under continuous laser irradiation. For the usage of hypoxic tumor treatment, TB was encapsulated by a block copolymer, poly(ethylene glycol)-b-poly(latic acid) (PEG(45)-b-PLA(24)), to fabricate phototheranostic nanoparticles (TB NPs). Due to the twisted molecular structure and the shielding effect of long alkyl chains, the pi-pi stacking-induced quenching of O-2(-center dot) could be reduced after the fabrication of nano-assemblies. Significantly, TB NPs exhibited satisfactory O-2(-center dot) generation for type I PDT and a simultaneously distinct photothermal conversion efficiency (PCE, 62%) for photothermal therapy (PTT) to combat hypoxic tumor cells. Moreover, the high PCE endowed TB NPs with high performance photoacoustic (PA) and photothermal imaging capability. In vivo experiments demonstrated that TB NPs possessed an outstanding phototherapeutic efficacy for eradicating hypoxic tumors. This study established a novel approach for constructing oxygen-independent phototherapeutic reagent against hypoxic tumors.