文献类型：期刊文献

英文题名：Ultralong Hydroxyapatite Nanowires-Based Paper Co-Loaded with Silver Nanoparticles and Antibiotic for Long-Term Antibacterial Benefit

作者：Xiong, Zhi-Chao[1];Yang, Zi-Yue[2];Zhu, Ying-Jie[1];Chen, Fei-Fei[1];Zhang, Yong-Gang[1];Yang, Ri-Long[1]

机构：[1]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China;[2]East China Univ Sci & Technol, Sino German Coll Technol, Shanghai 200237, Peoples R China

年份：2017

卷号：9

期号：27

起止页码：22212

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20172903958123);WOS:【SCI-EXPANDED(收录号:WOS:000405764700015)】；

基金：We acknowledge the financial support from the Science and Technology Commission of Shanghai (15JC1491001), the National Natural Science Foundation of China (21601199), and the Shanghai Sailing Program (16YF1413000).

语种：英文

外文关键词：hydroxyapatite; nanowires; paper; silver nanoparticles; drug delivery; antibacterial; ciprofloxacin

摘要：Hydroxyapatite is a kind of biocompatible, environmentally friendly, and versatile inorganic biomaterial. Herein, the preparation of ultralong hydroxyapatite nanowires (HAPNWs)-based antibacterial paper co-loaded with silver nanoparticles (AgNPs) and antibiotic is reported. HAPNWs are used to prepare AgNPs in situ using an aqueous solution containing AgNO3 under the sunlight without added reducing agent at room temperature. Subsequently, ciprofloxacin (CIP) as an antibiotic is loaded on the HAPNWs@AgNPs. The resultant HAPNWs@AgNPs-CIP paper possesses several unique properties, including high flexibility, high Brunauer-Emmett-Teller (BET) specific surface area (47.9 m(2) g(-1)), high drug loading capacity (447.4 mg g(-1)), good biocompatibility, sustained and pH-responsive drug release behavior (5.40-6.75% of Ag+ ions and 37.7-76.4% of CIP molecules at pH values of 7.4-4.5 at day 8, respectively), and reusable recycling. In the antibacterial tests against Escherichia coli and Staphylococcus aureus, the HAPNWs@AgNPs-CIP paper exhibits large diameters of inhibition zones and low minimum inhibitory concentrations (30 and 40 mu g mL(-1), revealing the high antibacterial activity. Besides, the consecutive agar diffusion tests (8 cycles), long-term stability tests (over 56 days), and continuous contamination tests (5 cycles) demonstrate the excellent recycling performance and long-term antibacterial activity of the HAPNWs@AgNPs-CIP paper. These results indicate a promising, potential of the HAPNWs@AgNPs-CIP bactericidal paper for tackling public health issues related to bacterial infections.