文献类型：期刊文献

中文题名：利福霉素S的固液相平衡和溶解热力学

英文题名：Solid-liquid phase equilibrium and dissolution thermodynamic properties of rifamycin S

作者：吴艳阳[1];李仁龙[1];丁毓[1]

机构：[1]华东理工大学化学工程研究所

年份：2019

卷号：47

期号：12

起止页码：49

中文期刊名：化学工程

外文期刊名：Chemical Engineering(China)

收录：CSTPCD;;Scopus;北大核心:【北大核心2017】；CSCD:【CSCD_E2019_2020】；

基金：上海浦江人才计划资助项目(16PJD019)

语种：中文

中文关键词：利福霉素S;溶解度;修正Apelblat方程;吉布斯自由能

外文关键词：rifamycin S;solubility;modified Apelblat equation;Gibbs free energy

摘要：在288.15-323.15 K温度范围内,采用静态法测定了利福霉素S在5种纯有机溶剂(乙醇、异丙醇、正丁醇、乙酸乙酯和乙酸丁酯)中的溶解度,结果显示:利福霉素S在5种溶剂中的溶解度均随温度的升高而增大。使用修正Apelblat方程对溶解度的实验值进行了关联,并采用X射线衍射仪测定利福霉素S的晶型。在范特霍夫方程的基础上,对溶解过程中相关的热力学参数进行了估算,所得的溶解焓和吉布斯自由能均为正值,从而说明该过程是吸热的,而当溶液饱和后继续溶解是需要吸收能量的;并且分析了溶解过程中不同溶剂条件下焓与熵的贡献率。为制得纯度更高的利福霉素S,整体优化利福平合成工艺提供了理论指导。
The solubility data of rifamycin S were measured in five pure solvents(ethanol,2-propanol,1-butanol,ethyl acetate and butyl acetate)across the temperature range of 288.15 K to 323.15 K by the static analytic method.The results demonstrate that the solubility of rifamycin S increass with the increasing temperature in the five pure solvents.The experimental data were correlated using the modified Apelblat equation.And the crystal form of rifamycin S was measured by X-ray powder diffraction.Furthermore,the relevant thermodynamic parameters of dissolution process were determined based on Van’t Hoff equation.The obtained dissolution enthalpy and Gibbs free energy are positive in all cases,which indicate that the dissolving process of rifamycin S is endothermic and more energy is needed for further dissolution when the solution reaches saturation.And the relative contribution rate of enthalpy and entropy is analyzed during the dissolution process in different solvents.All of these would guide the preparation of rifamycin S with high purity and optimization of the whole process of rifamycin preparation.