文献类型：期刊文献

英文题名：Creating micro-submicro structure and grafting hydroxyl group on PEEK by femtosecond laser and hydroxylation to synergistically activate cellular response

作者：Ji, Yinjun[1];Zhang, Haochen[1];Ru, Jiangying[2];Wang, Fan[3];Xu, Min[1];Zhou, Qirong[1];Stanikzai, Hamidullah[1];Yerlan, Ismailov[1];Xu, Zhiyan[3];Niu, Yunfei[1];Wei, Jie[3]

机构：[1]Second Mil Med Univ, Changhai Hosp, Dept Orthopaed, Shanghai 200433, Peoples R China;[2]Yangzhou Univ, Affiliated Hosp, Dept Orthopaed, Yangzhou 225009, Jiangsu, Peoples R China;[3]East China Univ Sci & Technol, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2021

卷号：199

外文期刊名：MATERIALS & DESIGN

收录：;EI(收录号：20210109725994);WOS:【SCI-EXPANDED(收录号:WOS:000633016100003)】；

基金：The grants were from the National Natural Science Foundation of China (81772343) , Shanghai Science and Technology support project (20S31900400) , the youth medical talents funding subject from the 13th fiveyear plan on science and education strengthening health project of Jiangsu province (QNRC2016356) .

语种：英文

外文关键词：Polyetheretherketone; Femtosecond laser; Micro-submicro structure; Functional group; Cellular response

摘要：Polyetheretherketone (PEEK) exhibits good biocompatibility and mechanical property but bioinert that does not activate the cellular response and stimulate bone regeneration. In the present study, to improve of bioactivity of PEEK, femtosecond laser technology was utilized to induce submicro structure on PEEK surface (FPK), which was subsequently treated by hydroxylation to create micro-submicro structure and simultaneously graft hydroxyl (-OH) group on FPK (FPKH). Compared with PEEK, FPK with submicro structure exhibited elevated surface prop-erty (roughness, hydrophilicity, surface energy and protein absorption). Moreover, FPKH with micro-submicro structure and-OH group further enhanced the surface property. In addition, compared with PEEK, FPK signifi-cantly activated the response (adhesion, proliferation, alkaline phosphatase activity and expressions of osteo-genic genes) of rat bone marrow stromal cells (BMSC) in vitro. Furthermore, compared with FPK, FPKH further enhanced the cellular response, which were the synergistic effects of micro-submicro structure and-OH group. In short, combination of femtosecond laser and hydroxylation treatment created micro-submicro structure and grafted functional group of-OH on PEEK with elevated surface property, which played key roles in activating cel-lular response. FPKH with pre-eminent cytocompatibility and bioactivity would have great potential for bone replacement. (c) 2020 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).