文献类型：期刊文献

英文题名：pH/GSH-responsive diselenide-containing micelle via backbone ketoxime cross-links for efficient drug delivery and controlled release

作者：Zhou, Chen[1];Yin, Wang[1];Zhao, Yuhao[2,3];Li, Yongsheng[2,3];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Shanghai Jiao Tong Univ, Dept Biliary Pancreat Surg, Renji Hosp, Sch Med, Shanghai 200127, Peoples R China;[3]Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200030, Peoples R China

年份：2024

卷号：210

外文期刊名：EUROPEAN POLYMER JOURNAL

收录：;EI(收录号：20241315822628);WOS:【SCI-EXPANDED(收录号:WOS:001218176700001)】；

基金：C. Z. and W. Y. contributed equally to this work. This work was supported by Shanghai Anticancer Association EYAS PROJECT (SACA- CY21C01) , Shanghai Jiao Tong university star of Jiao Tong university program medical and industrial cross research fund (No. YG2022QN027) and The Key Laboratory of Advanced Polymeric Materials of Shanghai.

语种：英文

外文关键词：pH/GSH-responsive; Drug delivery; Crosslinked micelle; Oxime; Diselenide-containing polymer; Controlled Release

摘要：Stimulus-responsive polymers are promising drug delivery systems for cancer therapy. However, low drug loading and drug leakage of polymeric carriers remain challenges. Here, a crosslinked diselenide-containing micelle was developed with pH/GSH dual responsiveness. Polyesters with multiple diselenide bonds and pendant ketone groups were synthesized by the ring-opening copolymerization of three cyclic monomers (diselenide-containing macrocyclic carbonate, 2-oxepane-1,5-dione, and 1,3-dioxan-2-one). The crosslinked polyester was obtained by the oxime click reaction of pendant ketone groups with hydroxylamine and then selfassembled into crosslinked micelle. This crosslinked micelle remained stable for 14 days, and responded to disassembly under the condition of pH = 5.0 and 10 mM glutathione (GSH). When the crosslinked micelle was loaded with the chemotherapeutic drug DOX, which possessed an active ketone group, the encapsulation efficiency of the crosslinked micelle increased to 91.36 %. The cumulative DOX release reached approximately 45 % under pH = 5.0 and 10 mM GSH. Importantly, the crosslinked diselenide-containing micelle could be taken up in MCF-7 breast cancer cells, responding to the tumor microenvironment and releasing encapsulated DOX. This crosslinked diselenide-containing micelle with pH/GSH dual responsiveness was proven to be a stable and efficient carrier with a promising application.