文献类型：期刊文献

英文题名：Highly diastereoselective and enantioselective Michael addition of 5H-oxazol-4-ones to α,β-unsaturated ketones catalyzed by a new bifunctional organocatalyst with broad substrate scope and applicability

作者：Huang, Huicai[1];Zhu, Kailong[1];Wu, Wenbin[1];Jin, Zhichao[1];Ye, Jinxing[1]

机构：[1]E China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2012

卷号：48

期号：3

起止页码：461

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000297704500040)，CCR-EXPANDED(收录号:WOS:000297704500040)】；

基金：We thank Shanghai Municipal Education Commission (11ZZ56), Shanghai Pujiang Program (08PJ1403300), and the 111 project (B07023) for financial support.

语种：英文

摘要：A new thiourea-tertiary amine bifunctional catalyst derived from L-tert-leucine was developed and provides excellent stereocontrol in a novel and direct Michael addition of 5H-oxazol-4-ones to alpha,beta-unsaturated ketones with much broad substrate scope. The conjugate addition products with chiral vicinal quaternary and tertiary stereocenters can be easily transformed to structurally interesting compounds or building blocks.