文献类型：期刊文献

英文题名：A pulsatile release platform based on photo-induced imine-crosslinking hydrogel promotes scarless wound healing

作者：Zhang, Jian[1];Zheng, Yongjun[2,3];Lee, Jimmy[1];Hua, Jieyu[2];Li, Shilong[1];Panchamukhi, Ananth[1];Yue, Jiping[1];Gou, Xuewen[1];Xia, Zhaofan[3];Zhu, Linyong[2];Wu, Xiaoyang[1]

机构：[1]Univ Chicago, Ben May Dept Canc Res, Chicago, IL 60637 USA;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Sch Chem & Mol Engn, Key Lab Adv Mat & Joint Int Res Lab Precis Chem &, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Burns Ctr Changhai Hosp, Shanghai, Peoples R China

年份：2021

卷号：12

期号：1

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000630057500002)】；

基金：We are very grateful to Dr. Bozhi Tian at the University of Chicago, and Dr. Elaine Fuchs at the Rockefeller University for sharing reagents and technical assistance. We thank Linda Degenstein at the transgenic core facility at University of Chicago for excellent technical assistance. The animal studies were carried out in the ALAAC-accredited animal research facility at the University of Chicago. This work was supported by grants NIH R01AR063630, R01OD023700, the Research Scholar Grant (RSG-13-198-01) from the American Cancer Society, the V scholar award from V Foundation to XW, and National Key Research and Development Program of China Grant (2019YFA0110500) to L.Z.

语种：英文

摘要：Effective healing of skin wounds is essential for our survival. Although skin has strong regenerative potential, dysfunctional and disfiguring scars can result from aberrant wound repair. Skin scarring involves excessive deposition and misalignment of ECM (extracellular matrix), increased cellularity, and chronic inflammation. Transforming growth factor-beta (TGF beta) signaling exerts pleiotropic effects on wound healing by regulating cell proliferation, migration, ECM production, and the immune response. Although blocking TGF beta signaling can reduce tissue fibrosis and scarring, systemic inhibition of TGF beta can lead to significant side effects and inhibit wound re-epithelization. In this study, we develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-beta inhibitor to achieve spatiotemporal specificity for skin wounds. The material enhances skin wound closure while effectively suppressing scar formation in murine skin wounds and large animal preclinical models. Our study presents a strategy for scarless wound repair. Dysfunctional and disfiguring scars can result from aberrant wound repair. Here, the authors develop a wound dressing material based on an integrated photo-crosslinking strategy and a microcapsule platform with pulsatile release of TGF-beta inhibitor to achieve spatiotemporal specificity for scarless wound repair.