文献类型：期刊文献

英文题名：Inflammation specific environment activated methotrexate-loaded nanomedicine to treat rheumatoid arthritis by immune environment reconstruction

作者：Tian, Jia[1,2];Chen, Tao[1,3];Huang, Baoxuan[2];Liu, Yang[1,4,5];Wang, Chao[2];Cui, Zepeng[2];Xu, Hao[1,4,5];Li, Qiang[1,4,5];Zhang, Weian[2];Liang, Qianqian[1,4,5]

机构：[1]Shanghai Univ Tradit Chinese Med, Longhua Hosp, 725 South Wanping Rd, Shanghai 200032, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Fudan Univ, Jingan Dist Ctr Hosp Shanghai, Shanghai 200040, Peoples R China;[4]Shanghai Univ Tradit Chinese Med, Spine Inst, 725 Wan Ping South Rd, Shanghai 200032, Peoples R China;[5]Shanghai Univ Tradit Chinese Med, Key Lab Theory & Therapy Muscles & Bones, Minist Educ, 1200 Cailun Rd, Shanghai 201203, Peoples R China

年份：2023

卷号：157

起止页码：367

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20225213310593);WOS:【SCI-EXPANDED(收录号:WOS:000938703900001)】；

基金：The authors thank the financial supports by the National Nat- ural Science Foundation of China (No. 81920108032 , 21875063) , the Natural Science Foundation of Shanghai (No. 21ZR1417800) , Shanghai Innovation Research Institute of Electronic Chemicals and the Fundamental Research Funds for the Central Universities (No. JKJ01221113) , State Administration of Traditional Chinese Medicine Young Qi Huang Scholar, Innovative team project of scientific re- search project of traditional Chinese medicine of Shanghai Municipal Health Commission (No. 2022CX001) , and Jingan District Health Research Project of Shanghai (No. 2022MS03) .

语种：英文

外文关键词：Rheumatoid arthritis; Methotrexate; Nanomedicine; Macrophage; Lymphatic function

摘要：Rheumatoid arthritis (RA), as an autoimmune inflammatory disease, is featured by enhanced vascular permeability, irreversible cartilage destroys and bone erosion. Although the pathogenesis of RA is still unclear, the immune environment, particularly the lymphatic system, which is instrumental to immune cell surveillance and interstitial fluid balance, plays vital roles in the process of RA. Herein, an inflammation specific environment activated methotrexate-encapsulated nanomedicine (MTX@NPs) was constructed for RA treatment, which accumulated in inflamed joints, and released MTX in the specific RA microenvironment. Notably, MTX@NPs could regulate the immune environment including reducing the expressions of inflammatory cytokines of macrophages and the inflammatory level of lymphatic epithelial cells (LECs), and ameliorating the lymphatic vessel contraction and drainage. In vitro and In vivo studies illustrated that MTX@NPs exhibited a high RA therapeutic efficacy and insignificant systemic toxicity owing to the suppression of the inflammation response and the improved lymphatic functions of RA joints. It suggests that the nanomedicine paves a potential way to the clinical practice of autoimmune diseases treatments via the regulation of immune environment and lymphatic functions.