文献类型：期刊文献

英文题名：Design, synthesis, and biological antitumor evaluation of tetrahydroisoquinoline derivatives

作者：Pang, Can[1];Zhao, Jianbo[1];Zhang, Shuai[1];Chen, Jiayu[1];Zeng, Xiu[1];Li, Hao[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China; East China Univ Sci & Technol, State Key Lab Bioreactor Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2024

卷号：109

外文期刊名：BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

收录：;EI(收录号：20240177787);WOS:【SCI-EXPANDED(收录号:WOS:001250381100001)】；

基金：We acknowledge the financial support provided by the China 111 Project (Grant B07023) .

语种：英文

外文关键词：Antitumor; In vitro; Quaternary ammonium salt; Synthesis; Tetrahydroisoquinoline

摘要：Cancer, as a public health issue, is the leading cause of death worldwide. Tetrahydroisoquinoline derivatives have effective biological activities and can be used as potential therapeutic agents for antitumor drugs. In this work, we designed and synthesized a series of novel tetrahydroisoquinoline compounds and evaluated their antitumor activity in vitro on several representative human cancer cell lines. The results showed that the vast majority of compounds showed good inhibitory activities against the cancer cell lines of HCT116, MDA-MB-231, HepG2, and A375.