文献类型：期刊文献

英文题名：Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines

作者：Chen, Jianzhong[1];Zhang, Zhenfeng[1];Li, Bowen[1];Li, Feilong[2];Wang, Yulin[2];Zhao, Min[2];Gridnev, Ilya D.[3];Imamoto, Tsuneo[4];Zhang, Wanbin[1]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Tohoku Univ, Grad Sch Sci, Dept Chem, Aoba Ku, Aramaki 3-6, Sendai, Miyagi 9808578, Japan;[4]Chiba Univ, Grad Sch Sci, Dept Chem, Chiba 2638522, Japan

年份：2018

卷号：9

外文期刊名：NATURE COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000451310400005)】；

基金：We would like to thank the National Natural Science Foundation of China (Nos. 21620102003 and 21702134), Science and Technology Commission of Shanghai Municipality (Nos. 15JC1402200 and 17ZR1415200), and Shanghai Municipal Education Commission (No. 201701070002E00030) for financial support. We thank the Instrumental Analysis Center of SJTU for characterization. We are grateful to Zhi-Xiang Yu, Peking University, and Yuanyuan Liu, East China Normal University, for helpful discussions concerning our mechanistic studies.

语种：英文

摘要：Asymmetric hydrogenation of sterically hindered substrates still constitutes a long-standing challenge in the area of asymmetric catalysis. Herein, an efficient palladium acetate (an inexpensive Pd salt with low toxicity) catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines is realized with high catalytic activities (S/C up to 5000) and excellent enantioselectivities (ee up to 99.9%). Quantum chemical calculations suggest that uniformly high enantioselectivities are observed due to the structurally different S- and R-reaction pathways.