文献类型：期刊文献

英文题名：Injectable, anti-collapse, adhesive, plastic and bioactive bone graft substitute promotes bone regeneration by moderating oxidative stress in osteoporotic bone defect

作者：Huang, Lei[1];Zhang, Shihao[2];Bian, Mengxuan[1];Xiang, Xingdong[1];Xiao, Lan[3];Wang, Jiayi[1];Lu, Shunyi[1];Chen, Weisin[1];Zhang, Cheng[1];Mo, Guokang[1];Jiang, Libo[1];Li, Yulin[2];Zhang, Jian[1]

机构：[1]Fudan Univ, Zhongshan Hosp, Dept Orthoped Surg, Shanghai 200032, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Mat Sci & Engn, Engn Res Ctr Biomed Mat,Minist Educ,Key Lab Ultraf, Shanghai 200237, Peoples R China;[3]Griffith Univ, Sch Med & Dent, Gold Coast, Qld 4222, Australia

年份：2024

卷号：180

起止页码：82

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20241815998488);WOS:【SCI-EXPANDED(收录号:WOS:001240567500001)】；

基金：This work was supported by the National Natural Science Foundation of China , (No. 81870965 , 8227245) , National Key Re- search and Development Program (2022YFC2405802) , Natural Sci- ence Foundation of Shanghai (21ZR1412300) , National Key R&D Program of China (2020YFC20 0840 0) .

语种：英文

外文关键词：Osteoporotic bone defect; Oxidative stress; Selenium nanoparticles; Osteogenesis; Anti-inflammation

摘要：The treatment of osteoporotic bone defect remains a big clinical challenge because osteoporosis (OP) is associated with oxidative stress and high levels of reactive oxygen species (ROS), a condition detrimental for bone formation. Anti -oxidative nanomaterials such as selenium nanoparticles (SeNPs) have positive effect on osteogenesis owing to their pleiotropic pharmacological activity which can exert anti -oxidative stress functions to prevent bone loss and facilitate bone regeneration in OP. In the current study a strategy of one -pot method by introducing Poly (lactic acid -carbonate) (PDT) and beta-Tricalcium Phosphate (beta-TCP) with SeNPs, is developed to prepare an injectable, anti -collapse, shape -adaptive and adhesive bone graft substitute material (PDT-TCP-SE). The PDT-TCP-SE bone graft substitute exhibits sufficient adhesion in biological microenvironments and osteoinductive activity, angiogenic effect and anti-inflammatory as well as anti -oxidative effect in vitro and in vivo . Moreover, the PDT-TCP-SE can protect BMSCs from erastininduced ferroptosis through the Sirt1/Nrf2/GPX4 antioxidant pathway, which, in together, demonstrated the bone graft substitute material as an emerging biomaterial with potential clinical application for the future treatment of osteoporotic bone defect.