文献类型：期刊文献

英文题名：Metabonomic study on women of reproductive age treated with nutritional intervention: screening potential biomarkers related to neural tube defects occurrence

作者：Jiang, Zhiting[1,2];Liang, Qionglin[1];Wang, Yong[2];Zheng, Xiaoying[3];Pei, Lijun[3];Zhang, Ting[4];Wang, Yiming[1];Luo, Guoan[1,2]

机构：[1]Tsinghua Univ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China;[3]Peking Univ, Inst Populat Res, WHO Collaborating Ctr Res Reprod Hlth & Populat S, Beijing 100084, Peoples R China;[4]Capital Inst Pediat, Beijing 100084, Peoples R China

年份：2011

卷号：25

期号：7

起止页码：767

外文期刊名：BIOMEDICAL CHROMATOGRAPHY

收录：;EI(收录号：20232414223663);WOS:【SCI-EXPANDED(收录号:WOS:000291450300005)】；

基金：The work was supported by a grant from the National Basic Research Development Program of China (973 Program, no. 2007CB511903).

语种：英文

外文关键词：UPLC-TOF MS; metabolic fingerprinting; biomarkers; nutritional intervention

摘要：Nutritional intervention is effective in reducing the risk of neural tube defects (NTDs). To determine the effects of nutritional supplementation on human metabolism, a metabonomic study was carried out on 96 women of reproductive age. Subjects with nutritional intervention were given fortified wheat flour (containing folic acid, vitamin B-1, vitamin B-2, ferric sodium edetate and zinc oxide) for 8 months. Serum metabolic fingerprinting was detected via ultraperformance liquid chromatography in tandem with time-of-flight mass spectrometry (UPLC-TOF MS), and data acquired was processed by multivariate statistical analysis. The result revealed a significant difference between the control and intervention group. Twenty potential biomarkers, including fructose 6-phosphate, sphingosine 1-phosphate, docosahexaenoic acid and hexadecanoic acid, were located and identified by the accurate mass measurement of TOF MS. These compounds are believed to be functionally related to anti-oxidative competence in vivo. In conclusion, metabonomics study is a valuable approach in exploring the effect mechanism of nutritional intervention on NTD prevention. Copyright (C) 2010 John Wiley & Sons, Ltd.