文献类型：期刊文献

英文题名：Performance Study of Biodegradable Supramolecular Novel Polyurethanes Derived from Different Carbon Chain Length Bio-Dicarboxylic Acids and Their Potential Applications

作者：Zhang, Xian[1,4]; Jiang, Shuai[1,5]; Zhao, Sipei[2]; Zan, Rui[3]; Chen, Xiang[3]; Shu, Mengxuan[3]; Lu, Xiao[3]; Tao, Suo[3]; Guo, Jianming[1]; Xin, Zhong[2]

机构：[1] Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; [2] Shanghai Key Laboratory of Multiphase Materials Chemical Engineering, Department of Product Engineering, East China University of Science and Technology, Shanghai, 200237, China; [3] Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China; [4] Shanghai Engineering Research Center of Biliary Tract Minimal Invasive Surgery and Materials, Shanghai, 200032, China; [5] Department of Urology, Zhongshan Hospital Wusong Branch, Fudan University, Shanghai, 200940, China

年份：2024

外文期刊名：SSRN

收录：EI(收录号：20240184964)

语种：英文

外文关键词：Biodegradable polymers - Biomechanics - Chain length - Chemical stability - Crosslinking - Fatty acids - Functional polymers - Medical applications - Physicochemical properties - Polyols - Polyurethanes - Structural properties - Tensile strength - Thermodynamic stability

摘要：The chemical structure of polyester polyols significantly influences the properties of polyester-based supramolecular polyurethane. This study involves synthesizing covalently cross-linked 3D network polyesters from polycondensation of glycerol with bio-derived aliphatic dicarboxylic acids (adipic acid, sebacic acid, and decanoic acid, with carbon chain lengths ranging from C4 to C10), followed by further supramolecular novel polyurethane synthesis with dicyclohexylmethane diisocyanate. A systematic analysis was conducted to investigate the relationship between the carbon chain units of the bio-dicarboxylic acid and the physicochemical properties of the supramolecular polyurethanes. The chemical structure, crystallization and melting behavior, thermal stability, mechanical properties, and biodegradable of the polyurethane were investigated by NMR, FT-IR, XRD, DSC, TGA and mechanical test. The crystallization and melting point of the polyols (PGA, PGS, PGD) gradually increased with increasing the carbon chain length (C4 to C10) units. The thermal stability, the ultimate tensile strength and elongation at break of the obtained PU polymer also gradually increased with the increasing carbon chain length units in the polyols. Besides, In vitro cell culture of adult mouse fibroblasts L929 cell showed good support for cell viability. Furthermore, the investigation delves into potential medical applications of these polymer, such as the development of biodegradable antimicrobial coatings with norfloxacin and their potential use as temperature-responsive scaffolds. All supramolecular polyurethanes exhibited body temperature (37℃) responsive behavior, and the shape recovery speed decreases gradually in the order of P(PGA)U, P(PGS)U, P(PGD)U. This research contributes valuable support for the development of customizable medical materials with specific mechanical properties, degradation behavior, and stimulus-responsive characteristics ? 2024, The Authors. All rights reserved.