文献类型：会议论文

中文题名：Temperature-control Strategy in an Industrial Clavulanic Acid Fermentation

作者：FENG TAO;ZHU XIAO-SHI;CHU JU;WANG YONG-HONG;ZHANG SI-LIANG;CAO BIN

机构：[1]State Key Laboratory of Bioreactor Engineering, National Engineering Research Center for Biotechnology,East China University of Science and Technology, 200237 Shanghai,China;[2]Shanxi Weiqida Pharmaceutical Co, Ltd, 037300 Datong, China;

会议论文集：The 12th Asian Pacific Confederation of Chemical Engineering Congress(第十二届亚太化工联盟大会暨化工展览会)论文集

会议日期：20080101

会议地点：大连

主办单位：中国化工学会;中国化工企业管理协会;中国石油和化学工业协会

语种：英文

中文关键词：clavulanic;acid;antibiotic;fermentation;temperature-control;dissolvedoxygen

摘要：is study investigates the effect of temperature-control strategy on the clavulanic acid fermentation in 50 L fermentor. Clavulanic acid was induced by the low growth rate at the end of idiophase when fermentation entered a production phasefrom a growth phase. Research examined the effects of temperature, 22 ℃、24 ℃、26 ℃ and 28 ℃, on clavulanic acid fernetation especially at the transition stage from growth to production. By analyzing and comparing the parameters denoting macro-metabolism, the productive metabolism after low temperature cultivation as low as 22 ℃ after 30 h was discussed. It was found that cultivation at appropriately low temperature did not influence the growth of cells, but also relieved oxygen deficit at the end of growth stage. Based on the above process analysis it was possible toselect a set of variables with which a temperature-control model was built. Finally a new temperature-control strategy was adopted and clavulanic acid production increased by 11.5%.