文献类型：期刊文献

英文题名：Design, synthesis and insecticidal evaluation of phthalic diamide analogs containing maleic diamide structures

作者：Pang, Xiwen[1];Han, Li[1];Zhou, Cong[1];Xu, Xiaoyong[1];Li, Zhong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：1

期号：2

起止页码：157

外文期刊名：ADVANCED AGROCHEM

收录：WOS:【ESCI(收录号:WOS:001590298700001)】；

基金：This paper is dedicated to the 60th anniversary of the pesticide discipline of Central China Normal University. This work was supported by the Innovation Program of Shanghai Municipal Education Commission (201701070002E00037) and the Fundamental Research Funds for Central Universities. National Key Research Program of China (2017YFD0200505).

语种：英文

外文关键词：Keywords; Diamide insecticide; Insecticidal activity; Maleic diamide; Scaffold hopping; Olefin

摘要：Substituting the benzene ring of flubendiamide by maleic diamide structures to adjust the conformation, a series of 24 novel compounds were designed and synthesized. All target molecular structures had been confirmed by satisfactory analytical and spectral data and evaluated the effects on major agricultural pests. According to the results of the insecticidal activity test, target compounds A2, B1, and B2 exhibited moderate mortality rates against Plutella xylostella at 200 mg & sdot; L-1. Finally, molecular docking revealed the possible binding mode of compound B2 with the target protein, ryanodine receptors.