文献类型：期刊文献

中文题名：避蚊胺-海藻酸钙微球的制备及其体外透皮吸收研究

英文题名：Preparation of DEET-calcium Alginate Microspheres and Evaluation of Its Percutaneous Penetration

作者：胡晏[1];王苏莉[1];余伟民[1];崔景斌[1]

机构：[1]华东理工大学药学院,上海200237

年份：2008

卷号：25

期号：2

起止页码：120

中文期刊名：中国现代应用药学

外文期刊名：Chinese Journal of Modern Applied Pharmacy

收录：CSTPCD;;北大核心:【北大核心2004】；CSCD:【CSCD_E2011_2012】；

语种：中文

中文关键词：避蚊胺;海藻酸钙微球;吸附;皮肤渗透

外文关键词：DEET ; calcium alginate microsphere ; adsoption ; percutaneous penetration

摘要：目的制备海藻酸钙空白微球,减少避蚊胺(DEET)的透皮吸收,延长其作用时间。方法采用溶剂挥发法制备海藻酸钙微球,采用光学显微镜和激光粒度仪考察微球特性;吸附DEET后制成霜剂,通过Franz扩散池,用气相色谱法考察含药微球的透皮吸收。结果所得微球外观圆整,平均粒径42.5μm,吸附量为1.2177g·g-1。透皮试验结果表明,海藻酸钙空白微球能延长DEET的释放,减少皮肤渗透。结论海藻酸钙微球具有显著的缓释效果,并减少DEET对人体及皮肤的不良反应。
OBJECTIVE Calcium alginate microsphcrc was prepared to decrease the pereutancous penetration of DEET for sustained release. METHODS The microsphere was prepared by solvent evaporation method and its property was characterized by the optical microscope and laser-diffraction granularity tester. The percutaneous penetration of DEET in cream was evaluated with Franz diffusion cell by gas chromatography. RESULTS The microsphere was spherical in shape and the mean diameter was 42. 5 m. The adsorption of DEET is 1. 2177g · g ^-1. The release of DEET from the microsphere could be sustained and the percutaneous penetration was decreased, too. CONCLUSION The calcium alginate microsphere possesses the character of sustained release and decrease the adverse effect of DEET.