文献类型：期刊文献

英文题名：Immunoregulative coating for scarless healing in anterior cruciate ligament reconstruction

作者：Wang, Shuang[1];Xu, Chao[4];Yu, Yuanman[1];Li, Jie[1];Chen, Tianwu[3];Wang, Jing[2];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Key Lab Ultrafine Mat, State Key Lab Bioreactor Engn, Minist Educ, Shanghai 200237, Peoples R China;[3]Fudan Univ, Huashan Hosp, Sports Med Dept, Shanghai 200040, Peoples R China;[4]Wuhan Text Univ, Coll Mat Sci & Engn, Wuhan 430200, Peoples R China

年份：2025

卷号：45

起止页码：71

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001359026100001)】；

基金：This research was supported by the Key Program of the National Natural Science Foundation of China (No. 32230059) , the Basic Science Center Program of the National Natural Science Foundation of China (No. T2288102) , the Foundation of Frontiers Science Center for Mate-riobiology and Dynamic Chemistry (No. JKVD1211002) , the National Natural Science Foundation of China (No. 32101086) , Key Research and Development Project of Shandong (No. 2023CXPT103) .

语种：英文

外文关键词：Anterior cruciate ligament; Scar tissue; Macrophages; Angiogenesis; Osteogenesis

摘要：Polyethylene terephthalate (PET) artificial ligaments are widely used in anterior cruciate ligament (ACL) reconstruction due to their high tensile strength. However, bone tunnel enlargement around PET ligaments poses a risk for surgical failure. PET's inert surface, lower bioactivity, and mechanical abrasion trigger an M1 macrophage-mediated inflammatory response, leading to excessive, disorganized scar tissue. This scar tissue creates a space-occupying effect at the interface, obstructing graft-bone integration and contributing to bone tunnel enlargement. To address this issue, we developed a multi-layered immune-regulating hydrogel coating for scar-free PET-bone integration. Comprising gelatin methacrylate (GelMA), polyethyleneglycol diacrylate (PEGDA), and sulfated polysaccharide (SCS), the hydrogel forms a hydrogen-bonded lubricating layer to reduce friction. The sustained release of SCS also down-regulates M1 macrophage polarization, inhibiting early scar formation. By eliminating the space-occupying effect of scar tissue, SCS subsequently promotes M2 macrophage polarization. This shift releases endogenous factors that enhance blood vessel formation and new bone growth, ultimately achieving high-quality graft-bone integration. The application of this multi-layered, inflammationmodulating hydrogel coating not only removes scar tissue barriers but also improves graft-bone integration through enhanced angiogenesis and osteogenesis. Moreover, it avoids the overuse of exogenous growth factors and potential complications, offering a more convenient and feasible therapeutic strategy.