文献类型：期刊文献

英文题名：Lanostane Triterpenoids from the Stems of Schisandra glaucescens

作者：Zou, Juan[1,2];Yang, Li-Bin[1];Jiang, Jing[3];Diao, Yan-Yan[3];Li, Xiao-Nian[1];Huang, Jin[3];Yang, Jian-Hong[1];Li, Hong-Lin[3];Xiao, Wei-Lie[1];Du, Xue[1];Shang, Shan-Zhai[1,2];Pu, Jian-Xin[1];Sun, Han-Dong[1]

机构：[1]Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650201, Peoples R China;[2]Chinese Acad Sci, Grad Sch, Beijing, Peoples R China;[3]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2012

卷号：78

期号：5

起止页码：472

外文期刊名：PLANTA MEDICA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000302397400011)】；

基金：This project was supported financially by the NSFC (No. 20802082 and 30830115), Chinese Academy of Sciences (projects KSCX2-EW-Q-10 and KSCX1-YW-R-24), Major State Basic Research Development Program of China (No. 2009CB522303 and 2009CB940900), Yong Academic and Technical Leader Rising Foundation of Yunnan Province (2006PY01-47), Natural Science Foundation of Yunnan Province (2005XY04 and 2006B0042Q), and Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China (awarded to Dr. Hong-Lin Li).

语种：英文

外文关键词：lanostane triterpenoids; Schisandraceae; Schisandra glaucescens; FXR

摘要：Ten new triterpenoids, schiglausins A-J (1-10), as well as four known compounds, were isolated from the stems of Schisandra glaucescens. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra and CD experiment. Compound 8 was determined to be a norlanostane triterpenoid. The crystal structure of compound 1 has been determined using single-crystal X-ray analysis while its absolute configuration was assigned on the basis of the CD spectrum. All isolates were tested for their FXR agonistic and antagonistic effects.