文献类型：期刊文献

英文题名：A Ruthenium Nitrosyl-Functionalized Magnetic Nanoplatform with Near-Infrared Light-Controlled Nitric Oxide Delivery and Photothermal Effect for Enhanced Antitumor and Antibacterial Therapy

作者：Yu, Ya-Ting[1];Shi, Shu-Wen[1];Wang, Yi[1,3];Zhang, Qian-Ling[3];Gao, Shu-Hong[2];Yang, Shi-Ping[4,5];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China;[4]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[5]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2020

卷号：12

期号：1

起止页码：312

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20200808198085);WOS:【SCI-EXPANDED(收录号:WOS:000507146100025)】；

基金：Financial support from the following funding is acknowledged: the National Natural Science Foundation of China (nos. 21571062 and 21271072 to J.G.L.; 21471101 and 21671137 to QL.Z.), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning to J.G.L., and Shenzhen Government's Plan of Science and Technology (JCY20150324140036843) to QL.Z.

语种：英文

外文关键词：nitric oxide delivery; ruthenium nitrosyl donor; magnetic nanoplatform; thermosensitive hydrogel; antitumor and antibacterial therapy

摘要：Developing a spatiotemporal-controlled nitric oxide (NO) delivery nanoplatform is highly desirable for its biological applications as a tumor inhibitor and antibacterial agent. In this study, a novel multifunctional magnetic nanoplatform {Fe3O4@PDA@Ru-NO@FA} (1) was developed for the near-infrared (NIR) light-controlled release of NO in which a ruthenium nitrosyl (Ru-NO) donor and a folic acid (FA)-directing group were covalently functionalized onto Fe3O4@PDA. Nanoplatform 1 preferentially accumulated in folate receptor-overexpressing cancer cell lines and magnetic field-guided tumor tissue, instantly released NO, and simultaneously produced a prominent photothermal effect upon 808 nm NIR light irradiation, leading to remarkable in vitro and in vivo antitumor efficacy. When nanoplatform 1 was treated only once, the potential MRI contrast agent was sufficient to significantly inhibit or eliminate the tumor tissues in living mice, thus offering opportunities for future NO-involved multimodal cancer therapy. In addition, a NO delivery nanoplatform {Fe3O4@PDA@Ru-NO} was imbedded in the matrix of a chitosan (CS)-poly(vinyl alcohol) (PVA) material to develop a hybrid thermosensitive CS-PVA/NO hydrogel. The CS-PVA/NO hydrogels demonstrated mild (<150 mW cm(-2)) NIR light-controlled NO delivery and thus produced an efficient antibacterial effect for both Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Therefore, these hydrogels have potential as antibacterial dressings for wound bacterial infection treatment.