文献类型：期刊文献

英文题名：Copper-catalyzed alkylarylation of activated alkenes using isocyanides as the alkyl source: an efficient radical access to 3,3-dialkylated oxindoles

作者：Zhao, Yaping[1,2];Li, Zhenghua[1];Sharma, Upendra K.[1];Sharma, Nandini[1];Song, Gonghua[2];Van der Eycken, Erik V.[1]

机构：[1]Univ Leuven KU Leuven, Dept Chem, Lab Organ & Microwave Assisted Chem, Celestijnenlaan 200F, B-3001 Louvain, Belgium;[2]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2016

卷号：52

期号：38

起止页码：6395

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000375624100010)，CCR-EXPANDED(收录号:WOS:000375624100010)】；

基金：Support was provided by the Research Fund of the University of Leuven (KU Leuven) and the FWO Fund for Scientific Research Flanders (Belgium). Y. Z. and Z. L. are grateful to the China Scholarship Council (CSC) for providing a doctoral exchange and doctoral scholarship, respectively. U. K. S. and N. S. are thankful to KU Leuven for providing a post-doctoral fellowship.

语种：英文

摘要：A novel and efficient protocol for the synthesis of 3,3-dialkylated oxindoles is described. The method involves a copper-catalyzed tandem radical addition/cyclization of N-arylacrylamides with the alkyl radicals generated from isocyanides. Two C-C bonds are formed in a single step.