文献类型：期刊文献

英文题名：Insertion of pH-sensitive bola-type copolymer into liposome as a "stability anchor" for control of drug release

作者：Hao, Weiju;Han, Xia;Shang, Yazhuo;Xu, Shouhong[1];Liu, Honglai

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：136

起止页码：809

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20154501507502);WOS:【SCI-EXPANDED(收录号:WOS:000367408100099)】；

基金：Financial support for this work is provided by the National Natural Science Foundation of China (No. 21276074), the 111 Project (No. B08021) of China and the Fundamental Research Funds for the Centre Universities of China.

语种：英文

外文关键词：Bola-type copolymer; pH-sensitivity; Liposome; Drug release

摘要：How to design intelligent carriers for delivering drugs to the target accurately and releasing drug timely with the help of a certain environmental stimulus is still a challenge in tumor treatment. In this work, pH-sensitive bola-type triblock copolymers, composed of poly(2-(diisopropylamino) ethylmethacrylate) (PDPA) and methoxy-poly(ethyleneglycol) (mPEG), were synthesized. Liposomes containing these copolymers (Liposome@Bola) have been prepared by simply mixing the copolymer with phospholipids and cholesterol. From the fluorescence polarization measurement, the stability of Liposome@Bola was found to be increased a lot comparing to the pure liposome. As a result, the doxorubicin (DOX) leakage of the former was restrained in neutral environment. However, when pH decreased from 7.4 to 6.0, DOX released percentage had been increased 30-60 points, which was heavily depend on the phospholipid composition. Furthermore, the size effects of PEG and PDPA segments were also investigated. These results indicated the synthesized bola-type copolymers improved the pH-controllability of drug release of liposome, i.e., increased the difference between the release amount under pH 7.4 and pH 6.0. The bola-type copolymer exhibited a good potential application in smartly controlling drug delivery system. (C) 2015 Elsevier B.V. All rights reserved.