文献类型：期刊文献

英文题名：Preparation of a novel sustained-release system for pyrethroids by using metal-organic frameworks (MOFs) nanoparticle

作者：Meng, Wenyan[1,2];Tian, Zhenfen[1,2];Yao, Pengji[1,2];Fang, Xialun[1,2];Wu, Tong[3];Cheng, Jiagao[3];Zou, Aihua[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Appl Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2020

卷号：604

外文期刊名：COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS

收录：;EI(收录号：20203008976181);WOS:【SCI-EXPANDED(收录号:WOS:000573286300005)】；

基金：The present study was supported by grants from the National Natural Science Foundation of China (No. 21872051) and the National Key Research and Development Plan (No. 2017YFD0200306).

语种：英文

外文关键词：Nanoscale metal-organic frameworks (NMOFs); Pyrethroids; Lambda-cyhalothrin; Insecticidal efficacy evaluation; Sustained release

摘要：In recent years, metal-organic frameworks (MOFs), especially nanoscale metal-organic frameworks (NMOFs) have been arisen as potential platform for delivery and sustained-release of drug molecules due to their excellent encapsulation performance. While, NMOFs used as carriers for pesticides have rarely been reported. Nanoscale UiO-66 had the potential to be used as a pesticide carrier due to its outstanding chemical and thermal stability, non-toxic and mass-production. In this work, lambda-cyhalothrin (LC) molecules were encapsulated in the nanoscale UiO-66 (LC@UiO-66) with ultrahigh drug loading (87.71 %) and good sustained-release property. The drug loading of LC@UiO-66 was higher than that of ever reported. LC@UiO-66 nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), fourier transform infrared (FT-IR) spectroscopy, thermogravimetric analysis measurements (TGA) and nitrogen adsorption-desorption isotherms. LC@UiO-66 nanoparticles had the cubic shape with an average particle size around 270 nm. The bioassay against Musca domestica (hygiene pests) showed that LC@UiO-66 had long-term insecticidal effect compared to the free LC and commercially available microcapsules, and the insecticidal activity of LC@UiO-66 was superior to commercially available microcapsules. Furthermore, LC@UiO-66 had an effective insecticidal effect against Aphis craccivora Koch (agricultural pests). All the above results demonstrated that LC@UiO-66 had excellent insecticidal effect in both public hygiene and agriculture. This study could expand the application of NMOFs as novel carriers for pesticides.