文献类型：期刊文献

英文题名：Asymmetric synthesis of isoquinolinonaphthyridines catalyzed by a chiral Bronsted acid

作者：Li, Jianjun[1,2];Fu, Yiwei[1,2];Qin, Cong[1,2];Yu, Yang[1,2];Li, Hao[1,2];Wang, Wei[1,2,3]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, State Key Lab Bioengn Reactor, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2017

卷号：15

期号：31

起止页码：6474

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000407450500004)，CCR-EXPANDED(收录号:WOS:000407450500004)】；

基金：This work was supported by the National Natural Science Foundation of China (21372073, 21572054 and 21572055), the Fundamental Research Funds for the Central Universities and the China 111 Project (Grant B07023).

语种：英文

摘要：A catalytic asymmetric method for the synthesis of chiral isoquino-linonaphthyridines has been developed. A chiral disulfonimide catalyzes a redox cyclization reaction between 2-methyl-3-alde-hydeazaarenes and 1,2,3,4-tetrahydroisoquinolines to deliver a range of isoquinolinonaphthyridines with good to high yields (up to 91%) and up to 92:8 er.