文献类型：期刊文献

英文题名：Direct C-2 acylation of indoles with toluene derivatives via Pd(II)-catalyzed C-H activation

作者：Zhao, Yaping[3];Sharma, Upendra K.[1];Schroder, Felix[1];Sharma, Nandini[1];Song, Gonghua[3];Van der Eycken, Erik V.[1,2]

机构：[1]Univ Leuven KU Leuven, LOMAC, Dept Chem, Celestijnenlaan 200F, B-3001 Leuven, Belgium;[2]RUDN Univ, Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia;[3]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2017

卷号：7

期号：52

起止页码：32559

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20172703891104);WOS:【SCI-EXPANDED(收录号:WOS:000404609800015)】；

基金：YZ is grateful to the China Scholarship Council (CSC) for providing a visiting doctoral fellowship. UKS and NS are thank ful to University of Leuven (KU Leuven) for a postdoctoral fellowship. FS is grateful t Flanders Innovation & Entrepreneurship (VLAIO) for providing a PhD scholarship. We acknowledge the support by COST (European Cooperation in Science and Technology) Action (CA15106) CH-Activation in Organic Synthesis. The research was. nancially support by The Ministry of Education and Science of the Russian Federation (the Agreement number 02.a03.0008).

语种：英文

外文关键词：Activation analysis - Acylation - Palladium compounds - Catalysis

摘要：A simple and efficient Pd-catalyzed method for the C2-acylation of indoles is described. Less toxic, stable, and commercially available toluene derivatives were used as acyl sources, with tert-butylhydroperoxide (TBHP) as oxidant and pivalic acid as additive, providing moderate to good yields.