文献类型：期刊文献

英文题名：Microencapsulation based on emulsification for producing pharmaceutical products: A literature review

作者：Huang, Hua-Jiang[1]; Chen, Xiao Dong[2]; Yuan, Wei-Kang[1]

机构：[1] School of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China; [2] Department of Chemical and Materials Engineering, University of Auckland, Private Bag 92019, Auckland, New Zealand

年份：2006

卷号：14

期号：3-4

起止页码：515

外文期刊名：Developments in Chemical Engineering and Mineral Processing

收录：EI(收录号：20062810002132)

语种：英文

外文关键词：Biocompatibility - Emulsification - Gelation - Multilayers - Organic polymers - Polyelectrolytes

摘要：In this paper, microencapsulation based on emulsification coupling with solvent evaporation, ionotropic gelation, coacervation technique, and spray drying are critically reviewed. The introduction of biocompatible polymers, especially polyelectrolytes, as wall-forming materials are included. Membrane emulsification, surface modification, preparation of multilayer microcapsules, characterization methods, as well as modeling of drug release are summarized. This review suggests that membrane emulsification coupled with the ionotropic gelation/complex coacervation is the most promising method for microencapsulation under the mild conditions. Multilayer microcapsules using layer-by-layer complex coacervation, are efficient in obtaining the desired properties.